ANTIOXIDANT AND ANTI-INFLAMMATORY PROPERTIES OF RHODIOLA ROSEA NANOPARTICLES IN AN INVITRO MODEL

Abstract

This study explores the potential of Rhodiola rosea nanoparticles as a novel therapeutic agent with remarkable antioxidant and anti-inflammatory properties. Rhodiola rosea, an adaptogenic herb traditionally recognized for its salutary effects on stress, fatigue, and overall well-being, is the focal point of this investigation. The research seeks to uncover the unique characteristics of nanoparticles derived from Rhodiola rosea and their profound impact on oxidative stress and chronic inflammation.

To formulate Rhodiola rosea nanoparticles, a controlled and precise nanoprecipitation method was employed. These nanoparticles were designed to encapsulate salidroside, a bioactive compound abundantly found in Rhodiola rosea and well-known for its antioxidant and anti-inflammatory properties. The encapsulation process was meticulously optimized to ensure efficient delivery of salidroside to target cells and tissues. Our findings illuminate the exceptional antioxidant capabilities of Rhodiola rosea nanoparticles. These nanoparticles effectively neutralized reactive oxygen species (ROS) and mitigated lipid peroxidation, demonstrating their potent antioxidative potential. This enhanced antioxidative effect is attributed to the improved bioavailability of salidroside when encapsulated in nanoparticles. Furthermore, our research unveiled the potent anti-inflammatory effects of Rhodiola rosea nanoparticles. They effectively modulated key inflammatory pathways, leading to a reduction in the secretion of pro-inflammatory cytokines. These effects have significant implications for ameliorating chronic inflammation, a pivotal factor in various debilitating diseases.

The study delves into the mechanisms of action of Rhodiola rosea nanoparticles, shedding light on their influence on NF-κB and MAPK pathways, as well as their ability to regulate oxidative stress-related enzymes. These insights provide a foundation for understanding the therapeutic potential of Rhodiola rosea nanoparticles. In conclusion, this original research underscores the tremendous potential of Rhodiola rosea nanoparticles as a natural remedy for oxidative stress and chronic inflammation-related disorders. The enhanced bioavailability of salidroside in nanoparticle form holds promise for the development of innovative and effective therapeutic interventions in the realm of natural medicine. Further investigation into the clinical applications of these nanoparticles is warranted, offering a promising avenue for the advancement of therapeutic strategies targeting oxidative stress and inflammation-associated diseases.

Keywords: Rhodiola rosea, nanoparticles, salidroside, antioxidant, anti-inflammatory